Misa took the puck into the zone and split two Winnipeg defenders before beating Connor Hellebuyck by the blocker.
Misa, who was the No. 2 pick in the 2025 NHL Draft, recorded his fourth career goal in 21 games after also scoring against Edmonton on Sunday.
Will Smith scored the tying goal early in the third period for the Sharks (29-25-4), who were coming off a 5-4 win against the Edmonton Oilers on Saturday after going 0-4-1 in the five games prior. Alex Nedeljkovic made his first start since Jan. 31 and made 27 saves.
Morgan Barron scored the lone goal for the Jets (23-26-10), who have gone 1-1-3 in their past five games. Hellebuyck made 21 saves.
Barron gave Winnipeg a 1-0 lead 2:44 into the first period. While skating down the left wing on a 2-on-1, Barron opted to shoot and beat Nedeljkovic over the glove.
Smith tied it 1-1 at 1:47 of the third period. Macklin Celebrini sent Collin Graf and Smith on a 2-on-1 before Graf's shot from the left slot rebounded off Hellebuyck to Smith, who knocked the puck out of the air and past Hellebuyck.