Jean-Gabriel Pageau and Anthony Duclair scored, and Mathew Barzal and Alexander Romanov each had two assists for the Islanders (14-15-7), who have won two of their past three games. Ilya Sorokin made 22 saves.
“Those are hard games, hard-fought games,” Cizikas said. “You know what needs to be done, night in and night out. We didn't veer away from [our game]. We accepted the challenge at hand, and the way our group played in the third period, there's a lot of good things to take away from that.”
Rickard Rakell had a goal and an assist, and Michael Bunting and Noel Acciari scored for the Penguins (16-16-5), who have lost two of their past three games. Tristan Jarry made 29 saves.
“I don't think we played as smart. We just didn't play a conscientious game like the game we've been playing for the last six weeks,” Pittsburgh coach Mike Sullivan said. “I just think our decisions with the puck weren't where they needed to be. We didn't play straight ahead. We talked about playing simple before the game, just the importance of simplicity and playing straight ahead. I just don't think we did it well enough.”
The teams will play the second game of a home-and-home at PPG Paints Arena in Pittsburgh on Sunday.
Brock Nelson scored at 4:51 of the first period, but the Penguins challenged the play for goaltender interference, and a video review determined that Duclair bumped into Jarry before the puck went in.
Pageau did give the Islanders a 1-0 lead at 14:47 of the first period. After he won an offensive-zone face-off, he skated toward the left post, where Barzal found him with a backdoor pass.