Ivan Ivan scored twice for the Avalanche (12-10-0), who had won three straight and six of seven. Justus Annunen allowed five goals on 16 shots; he gave up three goals on seven shots before he was pulled at 10:03 of the first period, then returned at the start of the third period. Alexandar Georgiev allowed three goals on 17 shots.
"No one is happy with the way we played tonight," Colorado coach Jared Bednar said. "I think a lot of guys were prepared to work and compete but our brains were not turned on, so then it turns into just chasing the game all over the place and execution got bad and ... yeah, just one of those nights."
Perbix gave Tampa Bay a 1-0 lead at 5:41 of the first period with a wrist shot from the top of the right face-off circle, with Michael Eyssimont providing a screen.
Guentzel extended the lead to 2-0 with a power-play goal at 7:46, whipping a wrist shot from the left circle that beat Annunen through the five-hole.
"We played well from the start to finish," Guentzel said. "It was a good 60 minutes. That's a high-offense team over there, so you've got to stay on them the whole time. I thought we did that from the start."
Ivan cut it to 2-1 at 8:56 when he stuffed in the rebound of a shot by Valeri Nichushkin.
"I take [the goals] as a positive for me, but I don't think it was acceptable the way we played," Ivan said. "I know it's the last game on the road trip, but this is not the way we wanted to end the road trip. This shouldn't happen anymore. We've got to be better."
Kucherov pushed the lead to 3-1 at 10:03 with a one-timer from the right circle to the short side off a pass from Hagel. Annunen was pulled after the goal.
Luke Glendening made it 4-1 with a short-handed goal at 13:15, scoring on the rebound of Hagel’s shot from the right circle on the rush. It was Glendening’s first goal of the season.
Hagel started the play by stealing the puck from Nathan MacKinnon in Tampa Bay’s defensive zone.
“[Hagel] was outstanding," Glendening said. "… It was a great play by him and he had an unbelievable night. It was fun to watch."
Cirelli extended it to 5-1 at 19:46 when he scored on a loose puck in the slot after Erik Cernak’s initial shot hit Colorado defenseman Samuel Girard.
Brayden Point scored on the power play to make it 6-1 at 9:38 of the second period.